Table IV.

Gene Ontology pathways and gene networks through which PDIA1 confers pro-oncogenic effects to ERα-positive breast cancer patients.

	Term	Description	Hits	Log P	Log (q-value)
1	GO:0010564	Regulation of cell cycle process	AURKA, CDC25A, CENPF, CKAP5, E2F8, ESPL1, FEN1, GTSE1, KIF11, KIF20A, PKMYT1, TACC3, TRIP13, TUBB, UBE2C	−42.08	−37.73
2	GO:0044770	Cell cycle phase transition	AURKA, CDC25A, CENPF, CKAP5, E2F8, ESPL1, GTSE1, PKMYT1, TACC3, TRIP13, TUBB	−37.03	−33.15
3	GO:0007346	Regulation of mitotic cell cycle	AURKA, CDC25A, CENPF, CKAP5, E2F8, ESPL1, GTSE1, KIF11, PKMYT1, RANBP1, TACC3, TRIP13, TUBB, UBE2C	−25.16	−21.80
4	GO:0000075	Cell cycle checkpoint	AURKA, CENPF, E2F8, GTSE1, TRIP13	−16.50	−13.66
5	GO:0044839	Cell cycle G2/M phase transition	AURKA, CDC25A, CENPF, CKAP5, GTSE1, PKMYT1, TUBB	−18.57	−15.61

AURKA, aurora kinase A; CDC25C, cell division cycle 25C; CENPF, centromere protein F; CKAP5, cytoskeleton associated protein 5; E2F8, E2F transcription factor 8; ESPL1, extra spindle pole bodies like 1, separase; FEN1, flap structure-specific endonuclease 1; GTSE1, G2 and S-phase expressed 1; KIF11, kinesin family member 11; KIF20A, kinesin family member 20A; PKMYT1, protein kinase, membrane associated tyrosine/threonine 1; RANBP1, RAN binding protein 1; TACC3, transforming acidic coiled-coil containing protein 3; TRIP13, thyroid hormone receptor interactor 13; TUBB, tubulin β class I; UBE2C, ubiquitin conjugating enzyme E2 C; UCP2, uncoupling protein 2.