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. 2022 Mar 3;185(5):916–938.e58. doi: 10.1016/j.cell.2022.01.012

Figure 3.

Figure 3

Single cell gene expression modules identify hallmarks of COVID-19 response

(A–H) Weighted gene correlation network analysis (WGCNA) of CITE-seq gene expression for major cell types.

(A) Association of module eigengenes with disease contrasts, clinical severity scores and variables, survival and gene set scores (∗all significant associations shown).

(B) Module pathway enrichment.

(C and D) p38MAPK.AP-1 module eigengene (C) correlation with AP-1 family genes (D) expression across patient groups.

(E–H) Eigengene expression and top eigengene-gene correlations for (E) ribosomal module in cMono (F) cycling module in cMono (G) JAK-STAT.interleukin module in CD4 and (H) FKB5.CD163 module in cMono. For all violin plots, median indicated by horizontal bar.