. 2022 Jan 14;28(2):216–229. doi: 10.3748/wjg.v28.i2.216

Table 3.

Overview of the diagnostic parameters for hepatocellular carcinoma

Diagnostic parameter (cut off)	Remark	AUROC
AFP (> 20 ng/mL)	Sensitivity: 40%–65%	0.54–0.80
AFP (> 20 ng/mL)	Specificity: 76%–96%	0.54–0.80
AFP-L3 (> 15%)	Sensitivity: 45%–90%	0.74–0.84
AFP-L3 (> 15%)	Specificity: 95%	0.74–0.84
AFP-L3 + AFP-P4 + P5 (> 15% for both biomarkers)	Sensitivity: 55.3%–61%	0.76
AFP-L3 + AFP-P4 + P5 (> 15% for both biomarkers)	Specificity: 82.3%–93.9%	0.76
AFP, AFP-L3 and DCP (3-25 ng/mL, 1%-10%, 0.48 ng/mL or 40 mAu/mL)	Sensitivity: 81%–93%	0.88–0.93
	Specificity: 69%-87%	0.88–0.93
AFP and GP73	Sensitivity: 75%-91%	0.91–0.95
AFP and GP73	Specificity: 81%-97%	0.91–0.95

AFP: Alpha-fetoprotein; DCP: Des-gamma-carboxyprothrombin.