Table 1.

Differences in flow deficit measurements between the original and modified signal compensation algorithm in healthy subjects

		Original	Modified
Thresholding Method	Parameter	Mean ± SD	Mean ± SD	P-value
Phansalkar	FD Count	938 ± 146	947 ± 190	0.709
	MFDS (μm2) (†)	1565 ± 467	1272 ± 252	0.001*
	FDD	0.18 ± 0.06	0.15 ± 0.06	<0.001*
MinError(I)	FD Count (†)	361 ± 77	350 ± 47	0.047*
	MFDS (μm2) (†)	10319 ± 2757	12152 ± 2149	0.008*
	FDD (†)	0.47 ± 0.12	0.51 ± 0.01	0.215
Li	FD Count	401 ± 79	365 ± 84	0.025*
	MFDS (μm2) (†)	10575 ± 4000	12360 ± 5537	0.011*
	FDD	0.49 ± 0.04	0.50 ± 0.03	0.049*
Phansalkar	MS-SSIM	0.36 ± 0.04	0.44 ± 0.02	<0.001*
MinError(I)	MS-SSIM	0.28 ± 0.06	0.39 ± 0.03	<0.001*
Li	MS-SSIM	0.28 ± 0.06	0.39 ± 0.03	<0.001*

Flow deficit and similarity indices before (original) and after (modified) removing hyporeflective regions in the inverted OCT were compared using pairwise analyses. All statistical tests for P-value column were parametric two-tailed paired samples t-tests, except those labelled (†) for nonparametric Wilcoxon signed ranks test. FD = flow deficit, FDD = flow deficit density, MFDS = mean flow deficit size, MS-SSIM = multiscale structural similarity index, SD = standard deviation. Asterisks indicate statistical significance (P-value of less than 0.05).