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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Biomed Pharmacother. 2021 Dec 22;146:112571. doi: 10.1016/j.biopha.2021.112571

Figure 4.

Figure 4.

Effects of NOS inhibition on fentanyl-induced changes in relative expiratory timing. L-NAME decreased relaxation time but minimally affected apneic pause. The negative effects of fentanyl on apneic pause were markedly augmented in the presence of L-NAME. Panels: Relaxation time (panel A) and apneic pause (expiratory time/relaxation time)-1), (Te/RT)-1) (panel B) prior to (pre) and following the administration of vehicle or L-NAME (50 μmol/kg, IV) and then fentanyl (25 μg/kg, IV) in unanesthetized adult Sprague Dawley rats. There were 6 rats in each group. The data are presented as mean ± SEM.