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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Biomed Pharmacother. 2021 Dec 22;146:112571. doi: 10.1016/j.biopha.2021.112571

Figure 7.

Figure 7.

Effects of NOS inhibition on the total fentanyl-induced changes in ventilatory parameters. Inhibition of NOS markedly alters the negative effects of fentanyl on many individual ventilatory parameters. Panels: The Total ventilatory responses elicited by vehicle or L-NAME (50 μmol/kg, IV) (panel A) or by fentanyl (25 μg/kg, IV) in the vehicle- or L-NAME-treated rats (panels B). There were 6 unanesthetized adult Sprague Dawley rats in each group. The data are presented as mean ± SEM. *P < 0.05, significant response. † P < 0.05, L-NAME-treated versus vehicle-treated.