Table 2.
Description of rats used in whole body plethysmography and baseline ventilatory parameters
| Parameter | Vehicle | L-NAME | D-NAME |
|---|---|---|---|
|
| |||
| Number | 6 | 6 | 6 |
| Age, days | 80 ± 2 | 81 ± 2 | 80 ± 2 |
| Body weight, grams | 328 ± 2 | 330 ± 2 | 331 ± 3 |
| Frequency, breaths/min | 99 ± 4 | 106 ± 4 | 103 ± 4 |
| Tidal Volume (TV), ml | 2.469 ± 0.045 | 2.323 ± 0.035 | 2.380 ± 0.051 |
| Minute Ventilation, ml/min | 245 ± 12 | 247 ± 9 | 243 ± 15 |
| Inspiratory time (Ti), sec | 0.203 ± 0.013 | 0.191 ± 0.011 | 0.197 ± 0.014 |
| Expiratory time (Te), sec | 0.375 ± 0.019 | 0.350 ± 0.025 | 0.368 ± 0.035 |
| End inspiratory pause, msec | 6.80 ± 0.23 | 7.18 ± 0.37 | 6.93 ± 0.33 |
| End expiratory pause, msec | 45.4 ± 7.7 | 47.5 ± 7.6 | 47.0 ± 6.5 |
| Peak inspiratory flow, ml/sec | 20.5 ± 1.2 | 21.5 ± 1.7 | 20.7 ± 1.9 |
| Peak expiratory flow, ml/sec | 16.2 ± 0.5 | 16.5 ± 1.6 | 17.0 ± 1.8 |
| EF50, ml/sec | 0.43 ± 0.06 | 0.46 ± 0.05 | 0.44 ± 0.07 |
| Relaxation time (RT), sec | 0.224 ± 0.010 | 0.206 ± 0.011 | 0.213 ± 0.022 |
| Apneic pause, (Te/RT)-1 | 0.78 ± 0.13 | 0.73 ± 0.07 | 0.76 ± 0.09 |
| TV/Ti, ml/sec | 12.5 ± 1.0 | 12.4 ± 0.7 | 12.1 ± 1.2 |
| TV/Te, ml/sec | 6.8 ± 0.4 | 6.9 ± 0.6 | 6.7 ± 0.8 |
| NEBI, % | 5.5 ± 0.5 | 5.6 ± 0.7 | 5.4 ± 0.6 |
| NEBI/frequency, %/(breaths/min) | 5.4 ± 0.5 | 5.3 ± 0.7 | 5.5 ± 0.8 |
NEBI, non-eupneic breathing index. The data are presented as mean ± SEM. There were 6 rats in each of the vehicle-treated and L-NAME-treated groups, and 6 rats in the D-NAME-treated group. There were no between group differences for any parameter (P > 0.05, for all comparisons).