Table 4.
Total responses elicited by D-NAME and fentanyl in D-NAME-treated rats
| D-NAME responses | Fentanyl responses | |||
|---|---|---|---|---|
|
|
|
|||
| Parameter | Vehicle | D-NAME | Vehicle | D-NAME |
|
|
|
|
||
| ΔFrequency, % | +4.7 ± 4.6 | +4.6 ± 3.9 | +5.2 ± 5.7 | +4.9 ± 3.3 |
| ΔTidal Volume, % | −2.9 ± 1.5 | −2.7 ± 1.8 | −12.9 ± 3.0* | −14.3 ± 2.1* |
| ΔMinute Ventilation, % | +1.9 ± 4.8 | +2.0 ± 4.1 | −7.1 ± 5.7 | −8.8 ± 5.2 |
The data are presented as mean ± SEM. There were 6 rats in the vehicle-treated group and 6 rats in the D-NAME-treated group.
*
P < 0.05, significant change from pre-value. There were no between group differences for any parameter (P > 0.05, for all comparisons).