Table 1.
Related enzymes and functions of RNA m6A.
| Type | Enzyme | Function | References |
|---|---|---|---|
| Writers | METTL3 | catalytic core, catalyzes m6A modification of RNA in vivo and in vitro | (25) |
| METTL14 | RNA binding platform that specifically recognizes binding target RNA: Stabilize the METTL3 structure | (25) | |
| WTAP | promotes recognition of m6A modification sites and activates the methyltransferase complex | (26) | |
| KIAA1429 | aggregates the methyltransferase complex at a specific site | (27) | |
| ZC3H13 | promotes localization of the m6A complex into the nucleus | (28) | |
| METTL16 | catalyzes m6A methylation of RNA | (29) | |
| RBM15/15B | helps to gather the enzyme complex to the target site | (30) | |
| ZCCHC4 | is involved in methylation of human 28S rRNA. | (31) | |
| Erasers | FTO | RNA demethylase | (32) |
| ALKBH5 | RNA demethylase | (32) | |
| Readers | YTHDC1 | promotes the transport and splicing of RNA | (33) |
| YTHDC2 | promotes RNA translation | (34) | |
| YTHDF1 | promotes RNA translation | (35) | |
| YTHDF2 | promotes RNA degradation | (36) | |
| YTHDF3 | interaction with YTHDF1 enhances its ability to promote mRNA translation or interaction with YTHDF2 enhances its ability to promote mRNA degradation | (37) | |
| HNRNPC | regulates the selective splicing and structural changes of RNA | (38) | |
| HNRNPA2B1 | regulates the selective splicing and structural changes of RNA | (38) | |
| eIF3 | promotes RNA translation | (35) | |
| IGF2BP1/2/3 | increases RNA stability and translation | (39) |