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. 2022 Jan 7;11:740676. doi: 10.3389/fonc.2021.740676

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Copyright © 2022 Recine, De Vita, Fausti, Pieri, Bongiovanni, Franchini, Casadei, Falasconi, Oboldi, Matteucci, Pallotti, Mercatali, Riva, Gurrieri, Vanni, Liverani, Miserocchi, Spadazzi, Cocchi and Ibrahim

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Response to therapy with larotrectinib: ¹⁸FDG-PET/CT scan evaluation. (A) Baseline FDG PET/CT study showing coronal fused PET/CT image with abnormal FDG uptake in multiple liver metastases, left rib and left femor. (B) Progressive metabolic response to larotrectinib after 7 days, four months, eight months and after almost one year of treatment. (C) Maximum intensity projection (MIP) PET/CT images: pre-therapy PET/CT scan again showed FDG-avid metastases occupying virtually the entire liver, left rib and left femor, all demonstrating high FDG avidity. (D) Seven days after the start of larotrectinib, PET/CT scan showed early tumor shrinkage with a reduction in FDG avidity in all previously described lesions.