Combining three acne treatments (an antibiotic, antibacterial, and retinoid) within an easy-to-use topical formulation could improve efficacy, tolerability, and treatment adherence. This is the first study of clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% (IDP-126) gel, which once approved will be the first triple-combination, fixed-dose topical acne treatment.

Results from this multi-center, randomized, double-blind study in children, adolescents, and adults with moderate-to-severe acne showed that over half of participants treated with IDP-126 gel achieved treatment success by week 12, with over 70% reductions in inflammatory and noninflammatory lesions.

Overall, IDP-126 demonstrated significantly greater efficacy vs vehicle gel and the three component dyad gels and was well tolerated over 12 weeks of daily use—making it a potential new treatment option in the acne armamentarium.