Table 3.

Results of local NMI improvements and Pearson correlation coefficient

	Baseline	A-RIR	H-RIR	P
NMI improvement mean ± SD (range)	0	0.225 ± 0.115 (0.036–0.466)	0.196 ± 0.114 (0.018–0.434)	<0.001
Pearson CC, mean ± SD (range)	0.721 ± 0.278 (0.039–0.980)	0.978 ± 0.024 (0.901–0.997)	0.972 ± 0.030 (0.876–0.996)	<0.001*1, 0.99*2

NMI: normalized mutual information, Pearson CC: Pearson correlation coefficient, A-RIR: automated rigid image registration, H-RIR: human rigid image registration,

^*1P-value result of one-way analysis of variance comparing the baseline vs A-RIR vs H-RIR

^*2P-value result of Post hoc Tukey’s test comparing A-RIR vs H-RIR