Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 7;12:797747. doi: 10.3389/fgene.2021.797747

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Ahlers, Falckenhayn, Holzscheck, Solé-Boldo, Schütz, Wenck, Winnefeld, Lyko, Grönniger and Siracusa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The cellular composition of dermal fibroblasts changes upon aging. (A) Experimental design. (B) Uniform Manifold Approximation and Projection (UMAP) plots of fibroblasts of young and old participants. (C) Expression of reticular (WISP2, SLPI, CTHRC1, MFAP5, TSPAN8), papillary (APCDD1, ID1, WIF1, COL18A1, PTGDS), pro-inflammatory (CCL19, APOE, CXCL2, CXCL3, EFEMP1) and mesenchymal (ASPN, POSTN, GPC3, TNN, SFRP1) markers (Solé-Boldo et al., 2020) among fibroblasts in UMAP plots. (D) Box plot of percentages of cells in fibroblast populations young vs. old, **** p<0.0001 (Fisher’s exact test). (E) Marker expression in UMAP plots, subclustering of population 4 into 4a and 4b. (F) Box plot of percentages of cells in fibroblast populations 4a and 4b young, vs. old, **** p<0.0001 (Fisher's exact test). F1-F4b Fibroblast populations 1–4b, yr years, y young, o old.