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. 2022 Jan 7;12:797747. doi: 10.3389/fgene.2021.797747

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Copyright © 2022 Ahlers, Falckenhayn, Holzscheck, Solé-Boldo, Schütz, Wenck, Winnefeld, Lyko, Grönniger and Siracusa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of Dermal sheath (DS) population and its loss upon aging in independent scRNA-seq datasets. Uniform Manifold Approximation and Projection (UMAP) plots of fibroblast populations from (A) Vorstandlechner et al., 2020, (B) Rojahn et al., 2020, (C) Tabib et al., 2020 and (D) Solé-Boldo et al., 2020. Violin plots of the average expression of the ten most upregulated genes of DS population (COL11A1, DPEP1, POSTN, TAGLN, MEF2C, MYL4, TNMD, WFDC1, GPC3, PPP1R14A) in these datasets. (E) UMAP plot of fibroblasts of other datasets integrated together with our dataset. Percentage of DS population young vs. old, n = 8 (young), n = 9 (old). *p < 0.05 (two-tailed unpaired t-test), mean +/- SEM. FB Fibroblasts, SR secretory-reticular, PI pro-inflammatory, SP secretory-papillary, M mesenchymal.