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. 2022 Jan 7;12:797747. doi: 10.3389/fgene.2021.797747

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Copyright © 2022 Ahlers, Falckenhayn, Holzscheck, Solé-Boldo, Schütz, Wenck, Winnefeld, Lyko, Grönniger and Siracusa.

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The dermal sheath population likely contains progenitor cells that are lost upon aging. (A) RNA velocity analysis of mesenchymal population 4, computed arrows indicating the extrapolated future states of the cells, bold hand-drawn arrows indicating 2 cell fates. (B) Stemness score of each cell in Uniform Manifold Approximation and Projection (UMAP) plots young vs. old. Violin plots of stemness score of (C) young populations, (D) young vs. old fibroblasts and (E) young vs. old populations. ***p < 0.001, ****p < 0.0001 (unpaired Wilcoxon rank sum tests). (F) Dot plot of the expression of genes accounting for “stemness” gene ontology terms by fibroblast populations. F1-4b Fibroblast populations 1–4b, y young, o old. % expr. Percent expressed, expr. average expression.