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. 2022 Jan 16;15:363–379. doi: 10.2147/JIR.S345108

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© 2022 Jiang et al.

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The hippocampal BDNF level in the SAE group was lower than that in the sham or SAE-EE group. The hippocampal BDNF level in the SAE-VP group was higher than that in the SAE group. No difference existed between the SAE group and SAE-MIX group. The hippocampal BDNF level in the SAE-EE group was higher than that in the SAE-EE-anti-VP serum, SAE-EE-shRNA, or SAE-EE-SR49059 groups. vs SAE: *p < 0.05, vs SAE: ^#p < 0.05, ^###p <0.001. Data represent the means ± standard error of the mean.

Abbreviations: EE, environmental enrichment; BDNF, brain-derived neurotrophic factor; VP, vasopressin; SAE, sepsis-associated encephalopathy; MIX, a mixture of VP and SR49059; shRNA, short hairpin RNA.