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. 2022 Jan 20;13:418. doi: 10.1038/s41467-021-27932-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The in vivo NIR images of small orthotopic pancreatic tumor by M1 and M2, and the ex vivo of organ biodistribution including heart, liver, spleen, lung, kidney, and tumor. The mean of three biological replicates is shown (n = 3). b The quantitative analysis of average fluorescence intensity per organ area p = 0.000844 < 0.001, (n = 3). c The in vivo NIR images of orthotopic pancreatic tumor with individual difference with the same i.v. dose administration for 12 h. The mean of five biological replicates is shown (n = 5). d The small size (~2 mm diameter) orthotopic pancreatic tumor images and its ex vivo signal distribution. e The quantitative calculation of the signal in tumor area and healthy spleen area. The mean of eight biological replicates is shown. (n = 10) f The tumor histochemical staining with Hochest3342 (blue), CD31 (green) and M1 (red) post i.v. injection of M1 for 48 h. The yellow arrows pointed at the blood vessels. Bars of the up layer: 200 μm; Bars of the bottom layer: 50 μm. Data: mean ± standard deviation. Injection dose (i.v. administration): 16 mg/kg. Statistical analysis: one-way t test followed by post hoc Tukey’s test, ***p < 0.001.