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. 2022 Jan 20;13:418. doi: 10.1038/s41467-021-27932-y

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Liver function indicators: alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), total protein (TP) and albumin concentration (ALB). The mean of four biological replicates is shown and data are presented as mean values ± SD (n = 4). b Blood biochemical indicators: creatinine (CREA), white blood cells (WBC), red blood cells (RBC), hematocrit (HCT), mean corpuscular volume (WCV), mean corpuscular haemoglobin concentration (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell volume distribution width-coefficient of variation (RDW-CV), platelet (PLT)and mean platelet volume (MPV). The mean of four biological replicates is shown and data are presented as mean values ± SD (n = 4). c Histologic sections of different organs: heart, liver, spleen, lung, kidney and pancreas compared with healthy group (PBS). Staining: H&E; Injection dose of M1. (i.v. administration): 16 mg/kg; Administration time: 24 h. Scale bar 200 μm.