Table 1.
The sequence, assembled behavior, targeting and tailoring capability of different designed molecules.
| Name | Molecular sequencea | Critical assembly concentration (CAC)b (μM) | Targeting receptor | Tailoring enzyme |
|---|---|---|---|---|
| M1 | mPEG-GPAKLVFFGC(IR783)GRGD | >500 | αvβ3 | FAP-α |
| M2 | mPEG-AGGKLVFFGC(IR783)GRGD | >500 | αvβ3 | – |
| M3 | mPEG-GPAKLVFFGCGRGD | >303.7 | αvβ3 | FAP-α |
| R-M1 | AKLVFFGC(IR783)GRGD | 37.2 | αvβ3 | – |
| M4 | mPEG-GPAKLVFFGC(IR783)GDTG | >500 | – | FAP-α |
| M5 | mPEG-AGGKLVFFGCGRGD | >332.7 | αvβ3 | – |
| R-M3 | AKLVFFGCGRGD | 19.2 | αvβ3 | – |
amPEG was methoxy polyethylene glycol with a molecular weight around 2000.
bThe CAC was analyzed based on pyrene.