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. 2022 Jan 20;12:1085. doi: 10.1038/s41598-022-04916-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of BEZ-235 on PI3K/AKT activity and on expression of BCL2 family members. Western blots (12% PAA gel) showing (a) dose- and (b) time-dependent effects of BEZ-235 on the expression of BCL2 family members and on phosphorylation of AKT, the mTOR target S6 and the BCL2 family member BAD. Dose-dependent effects were assessed after 24 h, time-dependent effects with a concentration of 300 nM BEZ-235. (c) Kinetics of apoptosis induced by BEZ-235 and AZD-5991 as determined by caspase 3/7 activity. Note that the kinetics of caspase 3/7 activity stimulated by BEZ-235 and AZD-5991 do not differ.