Table 2.
Cox’s proportional analyses of variables associated with 90-day mortality.
| Variables | Univariate analysis | P value | Multivariable analysis | P value |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Age (years) | < 0.001 | < 0.001 | ||
| < 75 | Reference | Reference | ||
| ≥ 75 | 1.273 (1.187–1.365) | 1.428 (1.328–1.536) | ||
| Sex | < 0.001 | 0.023 | ||
| Female | Reference | Reference | ||
| Male | 1.146 (1.067–1.230) | 1.088 (1.012 1.171) | ||
| SOFA score | 1.170 (1.159–1.181) | < 0.001 | 1.074 (1.055–1.093) | < 0.001 |
| APACHE II score | 1.077 (1.072–1.081) | < 0.001 | 1.024 (1.017–1.031) | < 0.001 |
| Charlson comorbidity index | 1.020 (1.007–1.003) | 0.002 | ||
| Subgroup of body temperature | < 0.001 | < 0.001 | ||
| > 38 °C | Reference | Reference | ||
| 36–38 °C | 1.402 (1.276–1.580) | < 0.001 | 1.353 (1.214–1.507) | < 0.001 |
| < 36 °C | 2.094 (1.825–2.402) | < 0.001 | 1.231 (1.067–1.421) | 0.004 |
| Septic shock | 2.288 (2.134–2.454) | < 0.001 | 1.613 (1.366 1.904) | < 0.001 |
| Mechanical ventilation | 2.564 (2.392–2.749) | < 0.001 | 1.464 (1.340–1.599) | < 0.001 |
| CRRT | 2.554 (2.360–2.764) | < 0.001 | 1.425 (1.302–1.560) | < 0.001 |
| Vasopressor use | 1.935 (1.805–2.074) | < 0.001 | 0.676 (0.570 0.802) | < 0.001 |
| Corticosteroid use | 1.584 (1.457–1.721) | < 0.001 | 1.215 (1.115–1.324) | < 0.001 |
| Transfusion | 1.621 (1.500–1.752) | < 0.001 | 1.251(1.153–1.358) | < 0.001 |
| Combination antibiotic therapy | 1.266 (1.176–1.362) | < 0.001 | 1.180 (1.095–1.272) | < 0.001 |
HR, hazard ratio; CI, confidence interval; SOFA, sequential organ failure assessment; APACHE, acute physiology and chronic health evaluation; and CRRT, continuous renal replacement therapy.