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. 2022 Jan 20;12:1102. doi: 10.1038/s41598-022-05050-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of expression of BBM-hypermethylated genes (candidate metastasis suppressor genes) correlates with survival in breast cancer patients. (A) Kaplan–Meier analysis shows that low expression of MIR124-2 correlates to poor relapse free survival (RFS) of breast cancer patients (p = 0.00004). (B) Kaplan–Meier analysis using a combined four-metastasis suppressor gene signature (BNC1, CCDC8, GALNT9 and MIR124-2) shows that loss of expression of these genes in combination correlates to poor RFS of breast cancer patients (p = 0.0046). (C) Low expression of MIR124-2 is associated with poor prognosis of ER + and ER- breast cancer patients (p = 0.007 and 0.017 respectively).