Table 1.
Unweighted and weighted cohort characteristics (N = 883,416) of unvaccinated individuals, CoronaVac, or Comirnaty recipients.
| Unvaccinated | CoronaVac | Comirnaty | Unvaccinated | CoronaVac | Comirnaty | ||
|---|---|---|---|---|---|---|---|
| Unweighted | Weighteda | ||||||
| n | 547,796 | 182,442 | 153,178 | 536,072 | 124,524 | 96,322 | Maximum weighted SMD |
| Age [mean (SD)] | 62.11 (12.85) | 61.58 (11.08) | 56.81 (13.43) | 61.08 (13.33) | 61.08 (11.31) | 61.08 (12.17) | <0.001 |
| Sex: male (%) | 229,791 (41.9) | 88,881 (48.7) | 72,586 (47.4) | 242587.9 (44.3) | 80814.1 (44.3) | 67831.5 (44.3) | <0.001 |
| Chronic conditions (%) | |||||||
| Hypertension | 367,799 (67.1) | 125,314 (68.7) | 93,319 (60.9) | 363621.4 (66.4) | 121104.0 (66.4) | 101688.5 (66.4) | <0.001 |
| Diabetes (type 2) | 180,875 (33.0) | 51,312 (28.1) | 36,403 (23.8) | 166524.0 (30.4) | 55471.7 (30.4) | 46570.1 (30.4) | <0.001 |
| Severe constipation | 45,405 (8.3) | 16,424 (9.0) | 13,804 (9.0) | 46915.4 (8.6) | 15619.6 (8.6) | 13111.6 (8.6) | <0.001 |
| Depression | 34,333 (6.3) | 10,745 (5.9) | 13,310 (8.7) | 36257.6 (6.6) | 12056.4 (6.6) | 10126.4 (6.6) | <0.001 |
| Cancer | 31,308 (5.7) | 4671 (2.6) | 4733 (3.1) | 25244.0 (4.6) | 8407.6 (4.6) | 7050.6 (4.6) | <0.001 |
| Hypothyroidism | 27,752 (5.1) | 9555 (5.2) | 9508 (6.2) | 29019.7 (5.3) | 9673.0 (5.3) | 8119.2 (5.3) | <0.001 |
| Chronic pain | 23,305 (4.3) | 7577 (4.2) | 7845 (5.1) | 24013.3 (4.4) | 8006.3 (4.4) | 6699.9 (4.4) | <0.001 |
| Asthma | 18,172 (3.3) | 5119 (2.8) | 7061 (4.6) | 18773.8 (3.4) | 6277.3 (3.4) | 5265.2 (3.4) | <0.001 |
| Chronic pulmonary disease | 12,090 (2.2) | 2638 (1.4) | 1663 (1.1) | 10152.9 (1.9) | 3373.7 (1.8) | 2846.7 (1.9) | <0.001 |
| Schizophrenia | 10,915 (2.0) | 1634 (0.9) | 1637 (1.1) | 8803.3 (1.6) | 2930.7 (1.6) | 2463.7 (1.6) | <0.001 |
| Rheumatoid arthritis | 7654 (1.4) | 1582 (0.9) | 1663 (1.1) | 6783.9 (1.2) | 2257.3 (1.2) | 1883.2 (1.2) | <0.001 |
| Peptic ulcer disease | 6662 (1.2) | 2224 (1.2) | 1583 (1.0) | 6502.3 (1.2) | 2162.0 (1.2) | 1810.1 (1.2) | <0.001 |
| Alcohol misuse | 4535 (0.8) | 1356 (0.7) | 1278 (0.8) | 4441.6 (0.8) | 1468.2 (0.8) | 1242.3 (0.8) | <0.001 |
| Cirrhosis | 3294 (0.6) | 544 (0.3) | 433 (0.3) | 2634.9 (0.5) | 876.7 (0.5) | 746.0 (0.5) | <0.001 |
| Parkinson’s disease | 3182 (0.6) | 409 (0.2) | 336 (0.2) | 2419.1 (0.4) | 811.4 (0.4) | 685.1 (0.4) | <0.001 |
| Dementia | 3030 (0.6) | 299 (0.2) | 204 (0.1) | 2184.8 (0.4) | 734.9 (0.4) | 607.3 (0.4) | 0.001 |
| Psoriasis | 2524 (0.5) | 721 (0.4) | 814 (0.5) | 2513.0 (0.5) | 836.6 (0.5) | 705.5 (0.5) | <0.001 |
| Irritable bowel syndrome | 1710 (0.3) | 621 (0.3) | 823 (0.5) | 1960.3 (0.4) | 652.3 (0.4) | 545.5 (0.4) | <0.001 |
| Inflammatory bowel disease | 1548 (0.3) | 360 (0.2) | 595 (0.4) | 1584.6 (0.3) | 514.3 (0.3) | 427.3 (0.3) | 0.002 |
| Peripheral vascular disease | 93 (0.0) | 9 (0.0) | 9 (0.0) | 91.5 (0.0) | 8.7 (0.0) | 13.9 (0.0) | 0.012 |
| Multimorbidity statusb (%) | 0.012 | ||||||
| One condition | 344,866 (63.0) | 128,890 (70.6) | 114,311 (74.6) | 363464.1 (66.4) | 121971.7 (66.9) | 102332.2 (66.8) | – |
| Two conditions | 168,166 (30.7) | 46,844 (25.7) | 34,071 (22.2) | 155986.2 (28.5) | 51013.4 (28.0) | 42906.3 (28.0) | – |
| Three conditions | 28,767 (5.3) | 5893 (3.2) | 4224 (2.8) | 23974.7 (4.4) | 7938.7 (4.4) | 6712.3 (4.4) | – |
| Four or more conditions | 5997 (1.1) | 815 (0.4) | 572 (0.4) | 4371.0 (0.8) | 1518.2 (0.8) | 1227.3 (0.8) | – |
| Adverse events of special interestb (%) | |||||||
| Cardiovascular system | 759 (0.1) | 160 (0.1) | 106 (0.1) | 737.8 (0.1) | 158.1 (0.1) | 118.0 (0.1) | – |
| Circulatory system | 689 (0.1) | 135 (0.1) | 113 (0.1) | 664.4 (0.1) | 131.6 (0.1) | 134.3 (0.1) | – |
| Hepato-renal system | 513 (0.1) | 148 (0.1) | 86 (0.1) | 508.3 (0.1) | 147.9 (0.1) | 85.7 (0.1) | – |
| Auto-immune diseases | 229 (0.0) | 40 (0.0) | 55 (0.0) | 233.5 (0.0) | 41.3 (0.0) | 50.6 (0.0) | – |
| Respiratory system | 154 (0.0) | 18 (0.0) | 10 (0.0) | 140.9 (0.0) | 17.9 (0.0) | 12.9 (0.0) | – |
| Other system | 113 (0.0) | 42 (0.0) | 43 (0.0) | 105.9 (0.0) | 43.3 (0.0) | 33.7 (0.0) | – |
| Nerves and central nervous system | 63 (0.0) | 14 (0.0) | 16 (0.0) | 59.5 (0.0) | 13.6 (0.0) | 16.6 (0.0) | – |
| Skin, bone, and joints system | 2 (0.0) | 1 (0.0) | 4 (0.0) | 1.7 (0.0) | 1.1 (0.0) | 2.9 (0.0) | – |
SMD standardized mean difference.
a Weighting variables: age, sex, hypertension, diabetes mellitus (type 2), severe constipation, depression, cancer, hypothyroidism, chronic pain, asthma, alcohol misuse, chronic pulmonary disease, schizophrenia, rheumatoid arthritis, peptic ulcer disease, cirrhosis, psoriasis, Parkinson’s disease, dementia, irritable bowel syndrome, inflammatory bowel disease, and peripheral vascular disease.
b Not included for weighting.