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. 2022 Jan 20;12:1049. doi: 10.1038/s41598-022-05013-4

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cells with high RBL2/low AURKA/B pathway genes are sensitive to PTX and irradiation therapies. (A) The indicated cell lines were plated in 96-well plates and treated with the indicated doses of PTX for 72 h and then analyzed with MTT. Relative average (8 technical replicate from one experiment) MTT absorbance is presented with SD indicated. (B) The indicated cell lines were treated with increasing doses of PTX (μM) for 48 h and then allowed to recover in drug-free media for 2–4 weeks. % average (3 technical replicate from one experiment) formed colonies are presented with SD indicated. There are significant differences (p < 0.05) between H460 and A549 p53+/+ cells treated with 1 μM, 5 μM, and 10 μM of PTX. There are significant differences (p < 0.01) between H460/A549 and HTB53/H1666 cells treated with all doses of PTX. There are significant differences (p < 0.05) between HTB53 and H1666 cells treated with all doses of PTX. There are significant differences (p < 0.05) between A549 p53+/+ and A549 p53−/− cells treated with 1 μM, 5 μM, and 10 μM of PTX. (C) The indicated cell lines were treated with 2 Gy, 4 Gy, or 6 Gy irradiation and then allowed to recover for 2–4 weeks. % average (3 technical replicate from one experiment) formed colonies are presented with SD indicated. There is no significant difference (p > 0.05) between H460 and A549 treated with all the doses of irradiation. There are significant differences (p < 0.01) between H460/A549 and HTB53/H1666 cells treated with all doses of irradiation. There are significant differences (p < 0.05) between HTB53 and H1666 cells treated with all doses of irradiation. There are significant differences (p < 0.05) between A549 p53+/+ and A549 p53−/− cells treated with all doses of irradiation.