Fig. 1. Cryo-ET of platelets from mice in different states.

Platelets from un-irradiated WT mice and BMT control mice had typical features including α granules, dense granules, gamma granules, mitochondria, intact membrane, microtubules, glycogen particles, and an open canalicular system (OCS). The platelets from AML mice (3 weeks) showed small round or oval shape without pseudopods. There were only glycogen particles and OCS inside. Platelets from pre-AML mice (1 week) can contain a mixture of normal and abnormal mitochondria. The example shown has only abnormal mitochondria. Color scheme used in segmentation is indicated in the panel. (Scale bar 1 µm).