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. 2022 Jan 20;5:72. doi: 10.1038/s42003-022-03009-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Roughly a quarter of mitochondria in pre-AML platelets were abnormal with reduced cristae and matrix (scale bar 100 nm). b 18.1% of the pre-AML platelets had one abnormal mitochondrion and 5.5% have more than one abnormal mitochondrion. c The statistical analysis of mitochondrial circularity (P < 0.0001) d ATP measurement assay for mitochondria in control and pre-AML platelets. e Gene set enrichment analysis (GSEA) on the platelets from pre-AML and control mice. “HYPOXIA” and “INFLAMMATORY_RESPONSE” were up-regulated and “MTORC1_SIGNALING” and “OXIDATIVE_PHOSPHORYLATION” were down-regulated in pre-AML platelets, compared with control platelets. Data in (c) and (d) are presented as mean ± s.e.m. Student’s t test was used for statistical analyses. *P ≤ 0.05.