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. 2022 Jan 20;12:1048. doi: 10.1038/s41598-022-05140-y

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Glucose metabolism is altered in older Pcyt2^+/− mice. (A) Fasting glucose levels for 2-mo and 8-mo Pcyt2^+/+ and Pcyt2^+/− mice. (B) Intraperitoneal glucose tolerance test for 2-mo and (C) 8-mo Pcyt2^+/+ and Pcyt2^+/− and area under the curve (n = 4). (D) Intraperitoneal pyruvate tolerance test for 2-mo and (E) 8-mo Pcyt2^+/+ and Pcyt2^+/− and area under the curve (n = 4). (F) Glucose production in primary hepatocytes (n = 12). (G) Relative mRNA expression levels of gluconeogenic enzymes G6Pase and Pepck (n = 4) and (H) G6Pase enzymatic activity (n = 12) in 8-mo Pcyt2^+/+and Pcyt2^+/− mice. (I) Relative mRNA expression levels of glycolytic enzymes Gk and L-Pk (n = 4) and (J) GK enzymatic activity (n = 12) in 8-mo Pcyt2^+/+ and Pcyt2^+/− mice. (K) [¹⁴C]deoxyglucose and (L) [³H]bromopalmitate uptake in liver (n = 6). (M) Periodic acid-Schiff staining of liver sections for glycogen in 8-mo Pcyt2^+/+ and Pcyt2^+/− mice. (N) Liver glycogen content of 8-mo Pcyt2^+/+ and Pcyt2^+/− mice (n = 12). Band intensities were measured using ImageJ. Data are presented as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.