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. 2022 Jan 20;5:80. doi: 10.1038/s42003-022-03031-6

Fig. 1. Selection of 23 tissue and cell types to perform transcriptome-wide association analyses (TWAS) for gut-brain axis (GBA) diseases.

Fig. 1

We selected 23 tissues and cell types previously found to contribute to the heritability of psychiatric or immune-mediated disease (Methods). Cross-tissue TWAS training and imputation models were used using transcriptome-wide and genome-wide reference data from 4043 reference samples from 23 tissues and cell types (Supplementary Data 2) provided by consortium projects GTEx, STARNET, and BLUEPRINT (Methods): gastrointestinal and liver tissues (n = 9), brain tissues (n = 10), whole blood (n = 1), and immune cell types (CD14+ monocytes, CD16+ neutrophils, CD4+ T-cells; n = 3). Different colors represent biological samples from different tissue classes. The size of the circles corresponds to the number of reference samples of the respective tissue.