Table 2.

Two-by-two contingency tables for clinical response at week 16 by early response in skin inflammation or itch at week 4 or week 8

Week 16 endpoint	Early-response assessment week	Sensitivity	Specificity	Positive predictive value	Negative predictive value
EASI75	Week 4	0.795	0.615	0.554	0.833
	Week 8	0.974	0.708	0.667	0.979
vIGA-AD (0,1)	Week 4	0.818	0.592	0.482	0.875
	Week 8	0.970	0.648	0.561	0.979
Itch NRS ≥ 4-point improvement	Week 4	0.917	0.575	0.393	0.958
	Week 8	1.000	0.588	0.421	1.000

Early response in skin inflammation or itch was defined as ≥ 50% improvement in BSA or ≥ 3-point improvement in Itch NRS, respectively

BSA body surface area, EASI Eczema Area and Severity Index, NRS Numeric Rating Scale, vIGA-AD (0,1) validated Investigator Global Assessment for Atopic Dermatitis score of 0 or 1