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. 2022 Jan 7;8:799051. doi: 10.3389/fmed.2021.799051

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Copyright © 2022 Xiang, Han, Wang, Chen, Shen, Zhu, Wang, Wei, Qin, Shushakova, Rong, Haller, Jiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI networks of DEGs and ROC curves for diagnosis of AR. (A) The PPI network of DEGs detected in AR vs. non-AR groups was performed with Cytoscape. (B) The hub genes were identified by the CytoHubba plugin with the top 10-degree score. (C) Box plots of the mRNA expression. (D) ROC curves were constructed to determine the diagnostic power of DEGs for AR. TNFSF14: AUC 79.5 (95% CI, 65.1–93.9); TANK: AUC 78.3 (95% CI, 63.4–93.1); ANKRD33B: AUC 80.5 (95% CI, 65.8–95.2); HSPA1B: AUC 79.3 (95% CI, 63.7–94.8); NFSF14+TANK+ANKRD33B+HSPA1B: AUC 92.3 (95% CI, 82.8–100).