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Pyroptosis pathways induced by IAV. The IAV progeny ribonucleoprotein complex (vRNP) is sensed by DAI via recruitment of RIPK3 to activate caspase-8. Caspase-8 may cleave GSDMD, and the N-terminal GSDMD fragment then activates NLRP3-dependent caspase-1. PB1-F2 can induce ASC speck formation, NLRP3 activation, and cleavage of caspase-1. M2 is translocated to the Golgi apparatus as a proton ion channel to alter the pH of intracellular compartments and activate inflammasomes.
