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. 2022 Jan 20;136(2):167–180. doi: 10.1042/CS20210865

Table 1. Metabolic and kidney function measurements in diabetic and control animals receiving either MCC950 treatment or vehicle only.

Short-term study (10 weeks of diabetes) Long-term study (18 weeks of diabetes)
Vehicle MCC950 in week 5–10 Vehicle MCC950 in week 9–18
Control Diabetes Control Diabetes Control Diabetes Control Diabetes
Body weight (g) 30.8 ± 0.5 25.8 ± 1.1*** 29.5 ± 0.5 25.9 ± 0.9** 31.7 ± 0.5 24.6 ± 1.4*** 30.7 ± 1.0 26.3 ± 1.4**
Right kidney/BW (mg/g) 6.17 ± 0.15 7.3 ± 0.40** 6.49 ± 0.17 6.91 ± 0.29 6.7 ± 0.16 8.44 ± 0.44*** 6.30 ± 0.13 7.95 ± 0.47***
Left kidney/BW (mg/g) 6.31 ± 0.16 7.20 ± 0.42* 6.31 ± 0.14 6.51 ± 0.20 6.8 ± 0.11 8.21 ± 0.39** 6.22 ± 0.13 8.09 ± 0.61***
P-glucose (mmol/l) 10.3 ± 0.4 25.7 ± 2.1*** 10.2 ± 0.6 23.6 ± 1.2*** 10.1 ± 0.4 30.6 ± 1.8*** 11.6 ± 0.6 29.3 ± 1.7***
HbA1c (%) 4.3 ± 0.2 9.1 ± 0.6*** 4.0 ± 0.1 8.1 ± 0.3*** 4.1 ± 0.1 9.7 ± 1.1** 4.4 ± 0.2 9.3 ± 1.0**
Systolic BP (mmHg) 99 ± 4.6 101 ± 4.6 88 ± 6.7 92 ± 6.8 98 ± 3.8 100 ± 3.2 103.8 ± 6.2 98.5 ± 5.9
Food intake (g) 2.9 ± 0.2 3.7 ± 0.2 2.8 ± 0.2 4.0 ± 0.4** 2.6 ± 0.15 5.1 ± 0.3*** 2.7 ± 0.3 4.3 ± 0.5***
Water intake (ml) 2.8 ± 0.6 10.1 ± 1.6*** 2.1 ± 0.3 9.5 ± 2.9*** 1.9 ± 0.3 17.0 ± 2.5*** 1.8 ± 0.2 15.3 ± 3.2***
Urine output (ml) 1.06 ± 0.17 9.9 ± 1.5*** 1.1 ± 0.14 8.7 ± 2.9*** 0.85 ± 0.17 15.56 ± 2.13*** 0.65 ± 0.14 13.69 ± 3.02***
Cystatin C (ng/ml) 300 ± 34 204 ± 19** 293 ± 24 224 ± 13* 230 ± 11 190 ± 12* 233 ± 13 176 ± 14**
ACR (mg/g) 45.1 ± 3.6 126.3 ± 17.5** 50.4 ± 3.1 104.4 ± 22.2* 30.2 ± 4.9 78.2 ± 13.8* 41.1 ± 6.5 160.5 ± 40.3**#

Data are presented as mean ± SEM. Abbreviations: ACR, urinary albumin-to-creatinine ratio; BP, blood pressure; BW; body weight; P; plasma. n=7–11 per group. Asterisks represent P-values for the comparisons of diabetes vs. control and diabetes+MCC950 vs. control+MCC950, respectively. *<0.05, **<0.01, *** <0.001. # represents P=0.06 for the comparison of diabetes+MCC950 vs untreated diabetes.