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. 2022 Jan 7;12:775046. doi: 10.3389/fimmu.2021.775046

Figure 1.

Figure 1

Diet-induced obesity promotes the local inflammatory response in male mice with periodontitis. (A–C) Representative flow cytometry plots and percentages of CD44+CD62L− and CD44−CD62L− cells in the CD4+ and CD8+ T cell populations from submandibular lymph nodes of either NCD-fed (n = 5) or HFD-fed (n = 5) male mice with periodontitis 9 days after ligature placement. (D–G) Frequency of TNF-α- or IL-17A-producing cells in the populations of CD4+ or CD8+ T cells in periodontitis-induced mice fed with either a NCD or a HFD. (H) Frequency of γδ T cells in submandibular lymph nodes of periodontitis-induced mice fed with either a NCD or a HFD. (I–K) Representative flow cytometry plots and percentages of either TNF-α- or IL-17A-producing cells in the population of γδ T cells from periodontitis-induced mice fed with either a NCD or a HFD. Data represent mean values of more than three independent experiments. Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01 [(C, G, H, K): two‐tailed t tests].