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. 2022 Jan 7;12:775046. doi: 10.3389/fimmu.2021.775046

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Copyright © 2022 Byun, Lee, Tian, Moon, Choi, Lee, Kim and Yi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical abstract. Exosomal miR-25-3p in saliva is highly enriched in patients with type 2 diabetes. Salivary exosomal miR-25-3p promotes local inflammation and periodontal bone loss in mice by activating T_H17 cells and γδ T cells.