Table 3.
Prognostic features for the AALL0232 cohort and training and test subjects.
| Characteristic | All AALL0232 (n = 156) | Training cohort (n = 109) | Testing cohort (n = 47) | P-value (training versus testing) |
|---|---|---|---|---|
| WBC at diagnosis, mean (range) K/µL | 78.412 (0.6–463) | 76.1 (0.6–374.7) | 84.2 (1–463) | 0.62 |
| CNS status at diagnosis, no. of patients | 0.30 | |||
| CNS1 | 138 | 91 | 34 | |
| CNS2 | 27 | 15 | 11 | |
| CNS3 | 5 | 3 | 2 | |
| ETV-RUNX1 fusion status | 0.11 | |||
| Positive | 32 | 16 | 13 | |
| Negative | 132 | 88 | 33 | |
| Unknown | 6 | 5 | 1 | |
| TCF-PBX1 fusion status | 0.94 | |||
| Positive | 8 | 5 | 1 | |
| Negative | 112 | 77 | 28 | |
| Unknown | 50 | 27 | 18 | |
| BCR-ABL1 fusion status | 0.23 | |||
| Positive | 6 | 6 | 0 | |
| Negative | 163 | 102 | 47 | |
| Unknown | 1 | 2 | 0 | |
| Trisomies 4/10 status | 0.53 | |||
| Positive | 23 | 17 | 5 | |
| Negative | 144 | 89 | 42 | |
| Unknown | 3 | 3 | 0 | |
| MLL status | 0.97 | |||
| Positive | 9 | 5 | 3 | |
| Negative | 158 | 101 | 44 | |
| Unknown | 3 | 3 | 0 | |
| Down syndrome | 1 | |||
| Positive | 2 | 1 | 1 | |
| Negative | 168 | 108 | 46 | |