Table 2.
Characteristics and physiological parameters of patients in the included studies
| Article, year | APACHE II score | P value | Intervention | 28 d Mortality (%) | P value | |||
|---|---|---|---|---|---|---|---|---|
| UFH | Control | UFH | Control | UFH | Control | |||
| Deng et al, 2017 [22] | 20.5 ± 4.2 | 21.8 ± 6.2 | P > 0.05 | UFH 7d (vein) | Usual care | 21.7 | 30.9 | P < 0.05 |
| Gu et al, 2014 [23] | 12 ± 9 | 16 ± 5 | P > 0.05 | UFH 5–10 U/(kg*h) 7d (vein) | Usual care | 23.8 | 33.3 | P > 0.05 |
| Guo et al, 2019 [24] | 15.22 ± 5.34 | 18.16 ± 5.53 | P > 0.05 | UFH 70 U/kg 5-7d (vein) | Usual care + saline | NR | NR | NR |
| Hou et al, 2011 [25] | 11.8 ± 3.5 | 15.3 ± 6.4 | P > 0.05 | UFH 3-4 U/kg/h 7d (vein) | Usual care | 15 | 25 | P = 0.429 > 0.05 |
| Jaimes et al, 2009 [26] | 9 (IQR: 7–13) | 10 (IQR: 6–14) | P > 0.05 | UFH 500 U/h 5-7d (vein) | Usual care + saline | 14 | 25 | P = 0.652 > 0.05 |
| Levi et al, 2007 [27] | 23.8 ± 7.6 | 24.0 ± 7.4 | P = 0.90 > 0.05 | UFH 5000 units bid (subcutaneously) | Usual care + saline | 29.3 | 31.9 | P > 0.05 |
| Liu et al, 2014 [28] | 20.82 ± 6.5 | 21.0 ± 6.69 | P = 0.935 > 0.05 | UFH 70 U/kg/24 h 5-7d (vein) | Usual care + saline | 31.8 | 40 | P = 0.434 > 0.05 |
| Liu et al, 2009 [29] | 12.67 ± 4.27 | 15.73 ± 7.27 | P = 0.708 > 0.05 | UFH 70 U/kg/24 h 5-7d (vein) | Usual care + saline | 33.3 | 36.4 | P = 0.643 > 0.05 |
| Peng et al, 2013 [30] | 15.22 ± 5.34 | 18.46 ± 5.53 | P > 0.05 | UFH 70 U/kg/24 h 5-7d (vein) | Usual care + saline | 12.5 | 28.6 | P < 0.05 |
| Wang et al, 2012 [31] | 18.7 ± 6.9 | 15.2 ± 6.2 | P > 0.05 | UFH 3-4 U/kg/h 7d (vein) | Usual care | 8.33 | 12.5 | P > 0.05 |
| Wu et al, 2011 [32] | 16.69 ± 4.12 | 18.89 ± 5.23 | P = 0.684 > 0.05 | UFH 5 U/kg/h 7d (vein) | Usual care | 17.78 | 37.5 | P < 0.05 |
| Zhang et al, 2006 [33] | NR | NR | P > 0.05 | UFH 3-4 U/kg/h 7d (vein) | Usual care | 27.3 | 27.3 | P < 0.05 |
| Zhao et al, 2009 [34] | 14.5 ± 4.2 | 14.8 ± 6.2 | P > 0.05 | UFH 40-50 mg/kg/24 h 5-7d (vein) | Usual care | 15.4 | 32.4 | P = 0.03 < 0.05 |
| Zhao et al, 2007 [35] | 20.54 ± 4.8 | 18.19 ± 3.69 | P > 0.05 | UFH 300 U/h 5d (vein) | Usual care + saline | 33.3 | 48 | P > 0.05 |
| Zhang et al, 2016 [36] | 11.7 ± 3.1 | 13.7 ± 7.6 | P > 0.05 | UFH 5 U/kg/h 7d (vein) | Usual care | NR | NR | NR |
NR not reported, UFH unfractionated heparin, APACHE II Acute Physiology and Chronic Health Evaluation II, IQR interquartile range