Table 1.
Cohort characteristics
| Characteristic | Cohort | Total (N = 48 835) |
|||
|---|---|---|---|---|---|
| COPDGene (n = 8395) |
Additional TOPMed studies (n = 11 269) |
ICGN and EOCOPD (n = 1554) |
UK Biobank (n = 27 617) |
||
| Median age, y (IQR) | 58.7 (51.8-66.3) | 60.0 (53.0-67.0) | 56.0 (49.7-63.1) | 58 (51.0-63.0) | 58.6 (51.3-64.0) |
| Patients with CHIP | 478 (5.7) | 566 (5.0) | 92 (5.9) | 1,588 (5.8) | 2,724 (5.6) |
| COPD GOLD status | |||||
| 2-4 | 3421 | 2282 | 1282 | 1459 | 8444 |
| 3-4 | 1698 | 945 | 853 | 149 | 3645 |
| Mean predicted FEV1% (SD) | 73 (25.6) | 87.7 (23) | 47.7 (26.8) | 100.8 (16.6) | 91.3 (24.2) |
| Smoking status | |||||
| Smokers | 8395 | 6515 | 1462 | 12 321 | 28 693 |
| Mean pack-years (SD) | 44.3 (25.0) | 16.1 (24.7) | 42.0 (26.7) | 6.2 (13.12) | 16.1 (24.1) |
Data represent no. (%) unless otherwise specified.
IQR, interquartile range; SD, standard deviation.