Fig. 2.

Utilizing Chl. to enhance PDT based tumor cell killing in vitro. a, Schematic diagram of Chl. coupled PDT for enhanced local effect in vitro. b, O₂ production of different amount of Chl. under light irradiation. c, Repetitive O₂ production of Chl. under light irradiation. d, Quantification of ¹O₂ of Ce6-NPs under 660 nm laser irradiation determined by SOSG. e, Quantification of the relative ROS intensity of CT26 cells. f, Cytotoxicity of CT26 cells treated with varied concentrations of Ce6-NPs under 660 nm laser exposure measured by CCK-8 viability reagent. Data are representative or pooled and are expressed as Mean ± SE. Asterisks indicate statistically significant differences as analyzed by One-Way ANOVA (∗∗∗ p < 0.001, ∗∗ p < 0.01, ∗ p < 0.05, N.S. p > 0.05).