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. 2022 Jan 7;12:798381. doi: 10.3389/fphar.2021.798381

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Copyright © 2022 Xuan, Piao, Ding, Nan, Piao, Jiang, Zheng, Jin and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative photomicrographs of immunohistochemistry for 8-OHdG (A), urine 8-OHdG concentration (B), immunoblotting analysis of MnSOD and NOX-4 (C), and intracellular ROS production in H₂O₂-treated HK-2 cells with or without Dapa and RIP inhibitors (D). Data are presented as mean ± SEM (in vivo, n = 6; in vitro, n = 3) and analyzed by one-way ANOVA. ^*** p < 0.01 vs sham or control; ^# p < 0.05 vs. UUO or H₂O₂.