Table 2.
The Effects of Mp.Cr on Various Parameters in Albino Rats using EG/AC-Induced Curative Urolithiasis Model.
| Day | Control | Intoxicated | Cystone (500 mg/kg) | Mp.Cr | ||||
|---|---|---|---|---|---|---|---|---|
| 100 mg/kg | 300 mg/kg | 500 mg/kg | ||||||
| Percent change in b.wt | 21st | 6.87 ± .51 | −8.46 ± .59 | −8.11 ± .66 | −7.76 ± .59 | −7.9 ± .86 | −8.47 ± .61 | |
| 35th | 7.07 ± .61 | 1.7 ± .53 | 5.4 ± .51*** | 2.57 ± .36*** | 3.17 ± .58*** | 4.75 ± .7*** | ||
| Crystal count (/mm3) | 21st | 5.16 ± 0.7 | 240.2 ± 7.32 | 224.7 ± 7.11 | 233 ± 7.1 | 238.3 ± 7.31 | 238.3 ± 9.03 | |
| 35th | 4.83 ± .74 | 233.3 ± 6.67 | 137.7 ± 8.04*** | 184.8 ± 12.95** | 159.3 ± 11.31** | 149.7 ± 12.35*** | ||
| Urinary Parameters (Urine/24 h) | Urine vol. (ml/24 h) | 21st | 9.3 ± 1.23 | 15.6 ± 1.1 | 16.1 ± 1.24 | 17.08 ± 1.13 | 16.63 ± 1.4 | 16.15 ± 1.5 |
| 35th | 9.73 ± 1.01 | 15.37 ± 1.43 | 11.87 ± .99** | 15.65 ± 1.34 | 14.02 ± 1.71* | 12.63 ± 1.02** | ||
| pH | 21st | 7.52 ± .21 | 4.99 ± .34 | 5.2 ± .27 | 5 ± .24 | 5.38 ± .36 | 5.18 ± .24 | |
| 35th | 7.22 ± .35 | 5.03 ± .23 | 7.08 ± .29** | 5.56 ± .33 | 6.56 ± .24 | 6.99 ± .24** | ||
| Oxalate (mg) | 21st | .38 ± .05 | 1.68 ± .13 | 1.66 ± .12 | 1.712 ± .08 | 1.720 ± 0.1 | 1.54 ± .13 | |
| 35th | .37 ± .08 | 1.67 ± .21 | .67 ± .09*** | .97 ± .07* | .95 ± .2** | .84 ± .11*** | ||
| Calcium (mg) | 21st | 3.21 ± .28 | 2.08 ± .22 | 2.09 ± .34 | 1.68 ± .21 | 1.74 ± .29 | 2.11 ± .23 | |
| 35th | 3.31 ± .27 | 2.06 ± .22 | 2.65 ± .25** | 1.89 ± .21 | 1.93 ± .19 | 2.45 ± .19** | ||
| Magnesium (mg) | 21st | 3.78 ± .29 | 1.86 ± .23 | 1.66 ± .17 | 1.48 ± .18 | 1.49 ± .21 | 1.42 ± .16 | |
| 35th | 3.73 ± .35 | 1.89 ± .21 | 2.94 ± .24*** | 2.03 ± .17** | 2.5 ± .13** | 2.83 ± .21*** | ||
| Uric acid (mg) | 21st | .65 ± .03 | 1.41 ± .08 | 1.52 ± 0.1 | 1.47 ± .09 | 1.45 ± .11 | 1.49 ± 0.1 | |
| 35th | .64 ± .05 | 1.41 ± .08 | .96 ± .07** | 1.25 ± .05 | 1.16 ± .07* | 1.04 ± .07** | ||
| Phosphate (mg) | 21st | 6.13 ± .41 | 8.58 ± 0.4 | 8.9 ± .41 | 8.25 ± .55 | 8.78 ± .35 | 9.01 ± .27 | |
| 35th | 5.82 ± .32 | 8.54 ± .27 | 6.22 ± .51*** | 7.66 ± .28 | 6.84 ± .27* | 6.5 ± .3** | ||
| Total protein (g) | 21st | 3.85 ± .51 | 8.97 ± 0.4 | 8.96 ± .67 | 8.76 ± .53 | 8.89 ± .49 | 9.11 ± .43 | |
| 35th | 4.03 ± .48 | 8.71 ± 0.5 | 5.36 ± .4*** | 7.46 ± .39 | 6.21 ± .61* | 5.82 ± .64** | ||
| Serum parameters | Creatinine (mg/dl) | 21st | .63 ± .06 | 1.53 ± .08 | 1.44 ± .11 | 1.34 ± .06* | 1.32 ± .06** | 1.35 ± .08 |
| 35th | .6 ± .07 | 1.55 ± .08 | .78 ± .08*** | 1.18 ± .03 | 1.11 ± .09** | .93 ± .06*** | ||
| BUN (mg/dl) | 21st | 18.46 ± 0.8 | 35.97 ± 1.28 | 32.25 ± 1.67 | 34.13 ± 1.37 | 31.79 ± 2.05 | 34.39 ± 1.64 | |
| 35th | 18.24 ± 0.7 | 35.72 ± 1.26 | 21.42 ± .93** | 29.58 ± 1.19 | 25.15 ± 1.85* | 24.07 ± 1.81** | ||