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. 2021 Dec 5;70(2):151–168. doi: 10.1369/00221554211061359

Figure 4.

Figure 4.

Differential levels of proteoglycans and GAGs in STICs. (A) Representative multispectral staining of hyaluronan, perlecan, or versican in benign (B), non-STIC (NS), and STIC (S) regions. Scale bar = 200 µm. (B) Quantification of epithelial MFI, stromal MFI, and epithelial:stromal ratio (E:S ratio) of hyaluronan, perlecan, or versican in B, NS, or S regions. Data are presented as box plots indicating median and range; dashed line demonstrates E:S = 1. *p<0.05 for S compared with B by Kruskal–Wallis test and Dunn’s multiple comparison posttest. n=10 (B), 11 (NS), and 8 (S). (C) Epithelial MFI, stromal MFI, and E:S ratio of patient-matched NS and S regions (indicated by connecting lines). Dashed line demonstrates E:S = 1. *p<0.05 by Wilcoxon matched-pair signed-rank test. n=8 patients. Abbreviations: GAG, glycosaminoglycans; STIC, serous intraepithelial carcinoma; MFI, mean fluorescent signal intensity.