FIGURE 8.

Schematic shows that the mechanical stretch stimulates APJ signalling during pressure overload, which involves dynamin‐dependent receptor endocytosis and activation of extracellular receptor kinase 1/2 (pERK1/2), leading to a hypertrophic response (red arrows). Stretch stimulates miR‐204 expression. miR‐204 suppresses APJ‐mediated stretch signalling and confers cardioprotection by triggering a shift to an alternate dynamin‐independent APJ endocytosis (green arrow) that neither activates pERK1/2 and nor promotes hypertrophic response of stretch