Figure 1.

Curcumin slightly extends median survival in HD flies. Survival probability of flies with unexpanded (elav>Httex1p Q20) and expanded glutamine repeats (elav>Httex1pQ93) fed without and with 10 µM concentration of curcumin from larval stages. Slight but notable improvement was observed in the median survival time of 10 µM curcumin-fed diseased flies, as compared to the unfed controls. Median survival (50%) is ∼5 days for elav>Httex1pQ93 which increased upto ∼7 days for 10 µM curcumin-fed diseased flies. Interestingly, 75% death time for diseased condition is just ∼11 days whereas it extends upto ∼13 days for 10 µM curcumin-fed diseased flies. Survival data was analyzed using Kaplan-Meier method followed by log-rank test [elav>Httex1p Q93 vs. elav>Httex1p Q93 (10 µM), P = 0.3049]. For each condition, n = 100 (20 flies/replicate, 5 replicates/condition). (A color version of this figure is available in the online journal.)