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. 2021 Jul 9;12:21. doi: 10.1007/s12672-021-00414-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MEG3 was downregulated in tumor tissues and inversely correlated with POU3F3 in melanoma tissues. The differential expression of POU3F3 in melanoma was also analyzed by measuring its expression levels in paired tumor and normal tissue samples collected from 60 melanoma patients. RT-qPCR data were compared by paired t test. Compared with adjacent normal tissues, MEG3 expression levels were significantly decreased in tumor tissues (A).* p < 0.05. Expression of MEG3 in tumor tissues was analyzed among patients with different clinical stages, and MEG3 expression level in tumor tissues decreased with the progression of cancer (B). Pearson’s correlation coefficient revealed that expression levels of POU3F3 and MEG3 were significantly and inversely correlated in tumor tissues (C) but not in normal tissues (D)