Fig. 2.

Multiple role of FAK in maintaining cancer malignancy. FAK kinase activation not only triggers ovarian cancer malignancy but also resulted in the recruitment of tumor-related cells including cancer-associated fibroblast, immune cells, endothelial cells as well as extracellular matrix remolding. FAK multiple roles in tumor progression evolution promise FAK inhibitor potential in mitigating tumor overgrowth, chemotherapy resistance, and immune escape