Table 3.
Urinary excretion of catecholamines and metanephrines in patients with metastatic and non-metastatic pheochromocytoma/paraganglioma
| mPPGL | non-mPPGL | P value | |
|---|---|---|---|
| Catecholamines, medians (IQR) (µg/day) | |||
| Urine free norepinephrine | 65.7 (31.2–299.4) | 86.2 (40.6–211.4) | 0.442c |
| Urine free epinephrine | 3.5 (1.9–6.5) | 19.1 (4.3–70.2) | < 0.001c |
| Metanephrines, medians (IQR) (µg/day) | |||
| Urine free normetanephrine | 280 (63.7–639.5) | 223.7 (98.5–471.8) | 0.9c |
| Urine free metanephrine | 19.3 (10.9–41.4) | 94.2 (22.3–347.5) | < 0.001c |
| False negative results, n (%)a, b | |||
| Catecholamines | 18 (48.6) | 34 (17.9) | < 0.001d |
| Metanephrines | 6 (16.2) | 9 (4.7) | 0.021d |
mPPGL metastatic pheochromocytoma/paraganglioma, non-mPPGL non-metastatic pheochromocytoma/paraganglioma, IQR interquartile ranges
aUrine samples from six mPPGLs and 16 non-mPPGLs were not available
bPatients with catecholamines or metanephrines below the upper cut-off
cMann–Whitney test
dChi-square test