Fig. 7.

BI853520 inhibits PI3K/AKT/mTOR signaling pathway in ovarian cancer cells. A, B Protein expression levels of p-PI3K/PI3K, p-AKT/AKT and p-mTOR(S2448)/mTOR were measured by western blot analysis in SKOV3 and OVCAR3 cells treated with BI853520 at different concentrations. GAPDH was included as the loading control. C–E. The histograms of gray values of p-PI3K/PI3K, p-AKT/AKT and p-mTOR(S2448)/mTOR western blot results. The data were presented as mean ± SD of three independent experiments. **P < 0.01