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. 2021 Nov 27;12:55. doi: 10.1007/s12672-021-00448-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — miR-26a negatively regulated E2F7-mediated transcriptional activation of VEGFA. A mRNA levels of VEGFA were overexpressed in PCa tissues. B, C The binding between E2F7 with the VEGFA promoter under different conditions was detected by CHIP. D The binding of E2F7 with the VEGFA promoter region was examined by luciferase reporter analysis. E The mRNA levels of VEGFA under the indicated conditions were compared via RT-qPCR. F, G The correlation between the expression of VEGFA with miR-26a or E2F7 in PCa tissues. ***P < 0.001