Table 1.

Drugs that influence the role of mitophagy in various tumors

Drug	Origin	Mechanism of action	Types of cancer
Dihydroergotamine tartrate (DHE)	Ergot alkaloid derivative	PINK1/Parkin-mediated mitophagy, increased ROS production, apoptosis induction	Lung cancer
Ketonazole	Antifungal drug	PINK1/Parkin-mediated mitophagy, COX-2 downregulation, apoptosis induction	HCC
Sorafenib	Multi-kinase inhibitor	PINK1/Parkin-mediated mitophagy, ETC complexes II and III inhibition, apoptosis induction	Renal cancer, liver cancer
AT101	BH3-mimetic	Mitophagic cell death	Glioma cells
Liensinine	Inhibitor of autophagy and mitophagy	Increases the sensitivity of cancer cells to chemotherapeutic drugs	Breast cancer
Melatonin	Hormone	Downregulation of JNK kinase and Parkin, apoptosis induction	Cervical cancer
Mdivi-1	Inhibitor of mitophagy	Enhanced the efficacy of chemotherapeutic drugs	Hepatic carcinoma