Table 4.
List of toxicity properties (organ toxicity, toxicity endpoints, Tox21-nuclear receptor signaling pathways, Tox21-stress response pathway) of the selected 2 compounds.
| Endpoint | Target | JQT | 51320 |
|---|---|---|---|
| Organ toxicity | Hepatotoxicity | Inactive | Inactive |
| Toxicity end points | Carcinogenicity | Inactive | Inactive |
| Immunotoxicity | Inactive | Inactive | |
| Mutagenicity | Inactive | Inactive | |
| Cytotoxicity | Active | Inactive | |
| LD50 (mg/kg) | 800 | 765 | |
| Toxicity class | 4 | 4 | |
| Tox21-nuclear receptor signaling pathways | Aryl hydrocarbon receptor (AhR) | Inactive | Inactive |
| Androgen receptor (AR) | Inactive | Inactive | |
| Tox21-stress response pathways | Heat shock factor response element (HSE) | Inactive | Inactive |